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| Breast Cancer Information |
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Are Obese Women Getting Short-Changed By Chemotherapy Treatments?
How much chemotherapy does an obese woman need? Typically an obese woman with breast cancer would receive reduced doses of chemotherapy as they battle breast cancer. Back in June of 2005, a study published in the Archives of Internal Medicine concluded that obese women should receive chemotherapy based on their actual weight, and not in reduced as amounts as it the standard practice. And now again a study presented in the August 2005 edition of Lancet claims that doctors should not reduce chemotherapy doses for obese women when no receptors for the hormone oestrogen have been found on the breast cancer cells. This type of cancer is called oestrogen-receptor negative. Clinicians often reduce chemotherapy doses for obese patients because of worries about how the treatment may react with the patient and affect their overall health. According to the study's director Marco Colleoni of the European Institute of Oncology, Italy, and his colleagues, reducing the first course of chemotherapy for obese patients with oestrogen-receptor negative breast cancer proves "detrimental". Colleoni and his team looked at the relation between body-mass index (BMI), chemotherapy dose reduction, oestrogen receptor expression, and outcome for pre-menopausal women with breast cancer by examining data from four randomized trials. They found that 97 out of 249 obese patients received less than 85% of protocol specified dose during the first course of chemotherapy compared with patients with normal and intermediate BMI. Obese patients with oestrogen-receptor negative disease that received 85% or more of the first protocol specified dose had significantly better disease-free survival and overall survival than those who received less than 85% of the normally recommended dosage. Yet, obese patients with oestrogen-receptor positive breast cancer who had reduced doses of chemotherapy did not have a significant difference in their outcome compared with those given the recommended chemotherapy doses. And contrary to popular practice, the researchers also noticed that obese patients initially treated with protocol doses of chemotherapy did not have more toxicity than patients who received reduced doses. Dr Marco Colleoni concluded that, "Our findings suggest that for women with ER-absent or ER-low tumours, reduction in chemotherapy dose should be avoided." The message for obese women coping with cancer is to be aware of your risks and rights. Ask your doctor will she recommend lower doses of chemotherapy for you based on your weight and ask why. Resources: Lancet, Archives of Internal Medicine Health author and Stanford University graduate Naweko San-Joyz lovingly writes from her home in San Diego. Her works include Acne Messages: Crack the Code of Your Zits and Say Goodbye to Acne (ISBN: 0974912204) and Skinny Fat Chicks, Why We're Still Not Getting This Dieting Thing (ISBN: 0974912212). Naweko created the Noixia philosophy to help people enhance their lives by connecting with their inner-mysteries and inner-selves. Her works take often over-looked, yet viable research and transforms in into practical tools that people can use to improve their health. Get useful, but too often ignored women's health news by visiting http://www.Noixia.com, Where Beauty Means Health.
MORE RESOURCES: Breastfeeding for at least six months might lower the risk of developing so-called "triple negative" breast cancer, an aggressive form of the disease that is more common in black and younger women, according to a study published on Monday in the journal Cancer, the Seattle Post-Intelligencer reports (Paulson, Seattle Post-Intelligencer, 8/24). A new promising enzyme target for a specific type of breast cancer, Brk, has been identified in research published on August 21, 2008 in the Proceedings of the National Academy of Sciences (PNAS.) In a specific subset of breast cancer patients, the tumor cells produce high levels of the protein ErbB2 (also called HER2) which pushes the cells to proliferate without limit, a characteristic common of all cancers. The American Medical Student Association (AMSA), the nation's oldest and largest, independent association for physicians-in-training, announces the commencement of AMSA Academy, a training ground for physician leaders. Established by students, for students, AMSA Academy takes medical students through the core competencies of leadership and project implementation, while building on key principles of important topics in medicine. There are currently 22 programs offered. Happiness and optimism may play a role against breast cancer while adverse life events can increase the risk of developing the disease, according to a study by Professor Ronit Peled, at Ben-Gurion University of the Negev in Israel. An article on the study titled "Breast Cancer, Psychological Distress and Life Events among Young Women," was just published in the British journal BMC Cancer (8:245, August 2008). Feelings of happiness and optimism play a positive role against breast cancer. Research published in the open access journal BMC Cancer suggests that while staying positive has a protective role, adverse life events such as the loss of a parent or close relative, divorce or the loss of a spouse can increase a woman's risk of developing the disease. New research may explain why breast cancer tends to be more aggressive in women with denser breast tissue. Breast cancer cells grown in dense, rigid surroundings step up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 issue of Current Biology. The findings suggest a cellular mechanism for the correlation between human breast tissue density and tumor aggressiveness. Two independent research groups have found that simultaneous inhibition of two signaling pathways resulted in substantially enhanced antitumor effects in mouse models of prostate and breast cancer. In an accompany commentary, Steven Grant, at Virginia Commonwealth University Health Science Center, Richmond, discusses the clinical importance of these studies and highlights some of the questions that still need to be answered. A new study published on bmj.com argues that for older women, health related quality of life can be improved by hormone replacement therapy (HRT). The authors recommend that HRT guidelines should be revised with this most current evidence taken into consideration. Earlier studies have shown that HRT has the potential for general improvements in quality of life measures - how patients feel or function. Duke University chemists have patented an efficient technique for synthesizing a marine algae extract in sufficient quantities to now test its ability to inhibit the growth of cancerous cells while leaving normal cells unaffected. The researchers also deduced that this molecule -- called largazole -- acts on cells through the same chemical mechanism as other anti-cancer compounds on the market or in clinical trials. Seeking to improve on nature, scientists used a spice-based compound as a starting point and developed synthetic molecules that, in lab settings, are able to kill cancer cells and stop the cells from spreading. The researchers are combining organic chemistry, computer-aided design and molecular biology techniques in developing and testing pharmaceutical compounds that can fight breast and prostate cancer cells. ImClone Systems Incorporated (NASDAQ: IMCL), a global leader in the development and commercialization of novel antibodies to treat cancer, today announced that the first patient has been treated in a global Phase 3 clinical trial of IMC-1121B, its anti-vascular endothelial growth factor receptor-2 (VEGFR-2) IgG1 monoclonal antibody, in women with metastatic breast cancer. Advocates, including those for breast cancer patients, are concerned about their relationship with pharmaceutical company Genentech following Roche's bid for the company, the A decade-long Nebraska study that showed disparities in breast and cervical cancer screenings could have spurred changes that raised the percentage of women screened in the state. "Disparities in screening between racial and ethnic groups, even in a homogeneous state such as Nebraska, are a problem and by digging into some of the differences we were able to have an impact on breast and cervical cancer screening," said lead study author Shingairai Feresu, Ph.D. Women who survive breast cancer for at least five years after treatment have an 89% chance that they will not have a recurrence of the cancer after 10 years and an 81% chance after 15 years, according to a study published online Tuesday in the Journal of the National Cancer Institute, Research by scientists at the University of Sheffield suggests that the combination of zoledronic acid (a drug used to prevent bone loss) and chemotherapy agent doxorubicin could stop the growth of breast cancer tumours. Dr Alexis Willett, Policy Manager at Breakthrough Breast Cancer, says: "Breakthrough welcomes any research which investigates new uses for existing treatments to help benefit people with breast cancer. An article published in The Lancet Oncology reports that postmenopausal women with breast cancer who are on endocrine treatment are likely to experience arthralgia and arthritis (joint symptoms) if they previously have used hormone replacement therapy (HRT), received a hormone-receptor positive tumor diagnosis, undergone chemotherapy, received treatment with anastrozole versus tamoxifen, or been obese. Scientists in the UK and Finland have discovered that a new combination of the chemotherapy drug doxorubicin and the bone-protecting drug zoledronic acid, both of which are considerably cheaper than herceptin, stopped breast cancer tumors growing in mice. Experts suggest that since both drugs are already in use, and if the combination proves effective and safe in human clinical trials, it should not take as long for it to be available as a new treatment for patients. Breast cancer patients and their physicians may make more informed, long-term treatment decisions using risk assessment strategies to help determine probability of recurrence, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reported in the Aug. 12 online issue of the Journal of the National Cancer Institute. Breast cancer patients and their physicians may make more informed, long-term treatment decisions using risk assessment strategies to help determine probability of recurrence, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reported in the Aug. 12 online issue of the Journal of the National Cancer Institute. Famous names from the fashion, television, radio and music industries have come together to back Fashion Targets Breast Cancer® (FTBC) UK in an advertising campaign which subtly plays on the topic of celebrity charity endorsement. Natalie Imbruglia, Anna Friel, Alan Carr, Edith Bowman and Twiggy have been shot by acclaimed photographer Rankin wearing their FTBC T-shirts with pride for the campaign from leading charity Breakthrough Breast Cancer which aims to raise £1m. US researchers estimated that the risk of relapse for breast cancer patients who were cancer-free for five years after systemic therapy (chemotherapy, hormone therapy, or both, as well as surgery) was not negligible although it was probably lower than many people realized. Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) announced that patient screening and dosing has begun in a Phase II trial designed to evaluate the safety and efficacy of bavituximab in combination with chemotherapy in patients with advanced breast cancer. American Airlines, the world's largest airline, and Susan G. Komen for the Cure®, the world's largest breast cancer organization, announced an expanded partnership with the unveiling of two specially co-branded aircraft, an American Airlines Boeing 757 and an American Eagle Embraer 145, each incorporating the renowned vivid pink-ribbon motif. Geron Corporation (Nasdaq: GERN) announced the enrollment of the first patient in a clinical trial of its telomerase inhibitor drug, GRN163L, in locally recurrent or metastatic breast cancer. The primary objective of the Phase I/II, dose escalation study is to determine the safety, maximum tolerated dose (MTD) and objective response rate of GRN163L when administered intravenously in combination with a paclitaxel/bevacizumab regimen in this patient population. A new discovery may lead to more effective screening and treatment for patients with a difficult to recognize syndrome characterized by tumor-like growths and a high risk of developing specific cancers. The research, published by Cell Press in the August 7 issue of the American Journal of Human Genetics, is the first in over thirteen years to identify an alternate susceptibility gene for Cowden syndrome (CS) and related disorders. |
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Breast Cancer Digest RELATED ARTICLES Naural Self-Defense Against Breast Cancer - Learning to Cope Successfully with Organochlorine Pollut What are organochlorines?Organochlorines are chemicals found in some herbicides and pesticides, in chlorine bleach and most chemical disinfectants, and many plastics, especially PVC (polyvinylchloride).Organochlorines are implicated in causing and promoting breast cancer because they mutate genes and they cause breast cells to become more receptive to a cancer-promoting chemical called estradiol. Finding Your Spiritual Strength in the Midst of Your Emotional Turmoil There were so many emotions that I experienced in 2003 when the doctor confirmed I had Breast Cancer; I was overwhelmed. That was a point in my life that seemed to play out in slow motion. Early Breast Cancer Detection Most women are familiar with mammography as our "gold standard" for breast cancer screening. However, there are additional tools available that women can add to their arsenal. Do You Know Some Nutrients Help Prevent Breast Cancer? Breast cancer today is one of the most threatening conditions that a woman might have. A woman's breast undergoes a lot of changes during her lifetime. Finding the Spirit - Identifying the Enemy In the daily fight for survival our vision is blurred because our health is compromised. This is when the enemy attacks- we lose focus and become vulnerable. Breast Cancer In December of 2001, breast cancer was the furthest thing from my mind. I was busy. Breast Cancer - 101 The cancer is a term for diseases in which abnormal cells divide uncontrollably invading near by tissue and spreading to other parts of the body via blood stream or lymphatic system.Similarly, in breast cancer, a single cell begins to divide and grow abnormally. Lets Start Screening For Breast Health In the United States, American women are told to begin annual mammographic screening for breast cancer at the age of 40. Long before we've reached this age, we are advised to perform a monthly breast exam and see our doctors for a clinical breast exam (CBE) annually as well. Mammogram and Breast Cancer Screening Cancer screening The term screening is commonly used for a test that is used for evaluation of a person for possible disease without the person ever having any symptoms or signs of the disease. Screening tests are usually undertaken in a target population, which has significantly high risk of developing the disease. Emotional Responses to Breast Cancer - Understanding the One You Love Being diagnosed with breast cancer is a life-changing event. A torrent of feelings wash over the survivor. Screening For Breast Cancer With No Compression And No Radiation Who would have thought that a technology for detecting breast cancer used today actually had its' roots dating back to 480 B.C. Recommendations For Early Breast Cancer Screening Women need to empower themselves about the benefits and risks of mammography and examine the additional screening tools available today. One current philosophy suggests breast health screening should begin at age 25. Fourteen Simple Things You Can Do To Reduce Your Risk for Breast Cancer 1. Increase your consumption of fresh, organic fruits and vegetables. My First Thermographic Experience I had been a bit nervous all day wondering what my thermogram procedure would entail. Would I need to undress completely? Would I be given one of those paper gowns that opens in the front and barely covers me? Would there be any heat coming out of the camera? I had been avoiding a mammogram after reading the latest information about the risks associated with X-ray; knowing that I was potentially putting myself at greater risk by not taking charge of my health. Victorious There it is again. I muttered to myself, frustrated as I washed my arm. A Tool for Early Breast Cancer Screening Who isn't familiar with the expression, "early detection is the best prevention?" We hear this term throughout the year and most everyone is familiar with this "catch phrase" as it relates to breast cancer. Obviously, a woman's chance for survival improves when a cancer is found early. New Hope to Prevent Breast Cancer: What Every Woman Needs to Know In March, 2005, a major nutritional breakthrough in the fight against breast cancer was announced by U.S. Digital Infrared Thermal Imaging In Medical Therapy Digital technology now makes Digital Infrared Thermal Imaging available to all. There now is a completely safe test that can aid in diagnosis, treatment and monitoring with absolutely no risk or radiation exposure. Antiperspirants And Breast Cancer Most underarm antiperspirants contain as the active ingredient, Aluminium Chlorohydrate, as you will probably remember there has been controversy about Aluminium, since the 1950's when it was a popular metal used for making cooking pots, Saucepans and Fry Pans and that it could be one of the contributing factors to Alzheimer's, now we have another problem that could also be related to Aluminium, Breast Cancer.Research shows that one of the leading causes of Breast Cancer could be the use of antiperspirants. The Insidiousness of Breast Cancer and Its Current Treatment In our modern world, the benefits that today's manufacturing and agricultural activities have brought us is more than painfully offset by the damage to our personal health and wellness. During the course of our daily lives, we are continually exposed to common household products such as detergents, insulation, fabric treatments, flame retardants, cosmetics, paints, upholstery preservatives, and coatings for electronic equipment.
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